Cardiac Pathology
Aortic Insufficiency Cor Triatriatum Mitral Insufficiency Total Anomalous Pulmonary Venous Return
Aortic Stenosis Corrected Transposition Mitral Stenosis Transposition of the Great Vessels
Aortopulmonary Window Double Outlet Patent Ductus Arteriosus Tricuspid Atresia
Atrial Septal Defect Ebstein's Malformation Pseudotruncus Tricuspid Insufficiency
Cardiac Tamponade Endocardial Cushion Defects Pulmonary Atresia Tricuspid Stenosis
Cardiomyopathies Hypoplastic Left Heart Syndrome Pulmonary Stenosis Truncus Arteriosus
Coarctation of the Aorta Left Ventricle-Right Atrial Communication Tetralogy of Fallot Ventricular Septal Defect
 

Repair Procedures


Aortic Insufficiency
         Increase in pulse pressure, LV becomes dilated and hypertropied
        Pulmonary congestion and edema are common
    Clinical Feature
        Cerebral insufficiency, dizziness, pulsating headaches, dyspnea, increased pulse pressure,
        and pulmonary congestion and edema. Coronary insufficiency mat occur
        Left heart failure followed by right heart failure
        Surgical replacement with a prosthetic valve is treatment.
Aortic Stenosis
        Increase in the systolic pressure within the left ventricle
    Clinical Feature
        Dizziness and fainting and angina pectoris are common. Easily fatigability exertional
        dyspnea and palpitations may also occur.
        Sudden death occurs in approximately 30% of cases
        Valve replacement is the treatment of choice.
    Supravalvular or Subvalvular or Idiopathic hypertrophic subaortic stenosis
Aortopulmonary Window
        Defect in which there is a opening between the aorta; near it's valve; and the pulmonary artery.
        This window functions as a patent ductus arteriosus pathology and clinical features are the same.
        Most cases shunt is large and increased pulmonary hypertension.
        Operative closure early is indicated, Correction contraindicated if shunt is right to left.
Atrial Septal Defect
        Most common defect in adults.
        Three types:
            1) Ostium primum- occurs low in septum and frequently associated with partial or complete cleft in medial mitral valve
            2) Ostium secundum- most common type usually located in the central portion of atrial septum.
            3) Sinus venosus- located high on the atrial septum near opening of SVC, occasionally anomalous drainage associated
    Clinical Features
        Some pulmonary hypertension may develop no cyanosis until right to left shunt occurs.
        Common atrium a secundum defect involving almost all of septum is rare.
Cardiac Tamponade
        Compression of the heart due to the collection of fluid (blood) within the pericardium
        Venous return to the right ventricle during diastole is restricted.
        Increased right ventricular end diastolic pressure
        Removal of blood from pericardium usually results in dramatic recovery.
Cardiomyopathies
        Term used for myocardial disease of unknown etiology
        Four classifications
            1) Hypertrophic-subdivided into conditions with or without obstruction.
            2) Congestive-characterized by congestive heart failure
            3) Obliterative- conditions in which the cavity of ventricle obliterated by abnormal tissue
            4) Restrictive- restricts ventricular filling extremely rare
Coarctation of the Aorta
        Most commonly found in the thoracic aorta distal to subclavian artery but may be located anywhere in aorta.
        Constriction can be pre or post ductal.
        Constriction usually produces arterial hypertension and left ventricular hypertrophy in proximal artery.
         Distal artery will show hypotension blood supply by collateral.
    Clinical Features
        Exertional dyspnea, frank congestive heart failure, hypertension, claudication in the low extremities.
        Defect repaired by resection of the coarctation and resuturing the aorta. Small tube graft may be used for large repair.
Cor Triatriatum
        Relatively rare congenital defect in which the left atrium is divided by a septum. commonly
            located transversely, divides the left atrium into two chambers.
        Posterior chamber receives all of the flow from the pulmonary veins, a small opening or
            openings connect the two left atrial chambers and offer high resistance to blood flow.
    Clinical Feature
        Pulmonary venous hypertension, pulmonary arterial hypertension, and right ventricular
            hypertrophy. Difficulty in breathing; exertional dyspnea and orthopnea
        Surgical correction involves excision of the septum between the left atrial chambers.
Corrected Transposition
        Defect of the great vessels are transposed but the ventricles are also transposed.
        Blood circulates in normal fashion venous blood passes through a mitral valve.
        Systemic blood passes through a tricuspid valve then out aorta.
    Clinical Features
        most of time no problem unless associated defects VSD, pulmonary stenosis, MV
        abnormalities and disturbance in the A-V conduction system.
        Surgical Jatene or Le Compte
Double Outlet
    When ventricular septum so grossly deformed that it appears to be absent. ASD and transposition commonly found
     Surgical correction is difficult and unsuccessful in most cases.
        Double outlet right ventricle both aorta and pulmonary artery leave RV may appear to be Tetralogy of Fallot or VSD
        Sometime referred to as partial transposition.
Ebstein's Malformation
        Part of the septal and posterior leaflets are attached directly to the right ventricular wall
        Divides the RV into two parts; proximal RV (atrialized part) and distal or functional RV
        Patent foramen ovale or ASD common finding.
        Tricuspid insufficiency common and occasionally tricuspid stenosis is also present
    Clinical Feature
        Dyspnea, cyanosis and clubbing are common. Cardiac arrhythmias common.
        70% pts untreated die before age 20 many suddenly.
        Valvuloplasty indicated in only 30%
Endocardial Cushion Defects
        Two ridges of embryonic tissue which fuse and close the atrioventricular canal and the septal cusps of the mitral and
            tricuspid valves.
        Three types:
            1) Ostium primum defect
            2) Ostium primum defect is present and clefts in both the mitral and tricuspid leaflets. Small bridge of tissue interrupts
                this cleft and prevents it from becoming a common valve. A small VSD may be present.
            3) Ostium primum defect and continuous cleft through both the mitral and tricuspid common valve to both sides.
                This is called atrioventricular communis (A-V canal)
    Clinical Features
        Dyspnea and fatigue common as are respiratory infections.
        70% infants with defect die within the 1st yr of life.
        ASD repaired by direct closure. Clefts are sutured closed.
Hypoplastic Left Heart Syndrome
        Underdeveloped left side of the heart.
        Aortic valve atresia, extreme hypoplasia of the aorta, mitral valve atresia or hypoplasia
        Foramen ovale usually opened and a patent ductus arteriosus along with intact ventricular
            septum
        Fourth most common defect accounts for 25% of cardiac deaths during the 1st month.
        Staged Norwood procedure only treatment.
Left Ventricle-Right Atrial Communication
        A high VSD connecting the left ventricle with the right atrium surgical correction by direct closure
Mitral Insufficiency
        Incomplete closure or absence of a mitral valve.
        Increased filling in left ventricle which results in dilation and hypertrophy.
        Peak pressure in atrium can reach 50-70 mmHg
        Increased pulmonary artery and RV systolic pressures
    Clinical Feature
        Palpitations, fatigue, orthopnea, and pulmonary edema secondary to LV volume overload
        Right heart failure may occur
        Treatment is prosthetic valve replacement usually.
Mitral Stenosis
        Most common valvular defect.
        Rise in left atrial pressure due to slowed flow to ventricle during diastole
    Clinical Feature
        Palpitations, weakness, orthopnea, dyspnea, pulmonary edema, and hemolysis common
        Edema and cyanosis may occur in advanced stages.
        Usually valve replacement or mitral commissurotomy are repair.
Patent Ductus Arteriosus
        Should form ligamentum arteriosum within 12 days of birth.
    Clinical Features
        Left to right Shunt; dyspnea, fatigue, diminished growth, and cardiac failure if the shunt is large.
        Subacute bacterial endocarditis may develop.
        Could be right to left shunt if pulmonary resistance is higher than systemic; cyanosis and fatigue main complaints.
        Ductus is closed by ligation and/or complete division, When shunt is right to left surgical correction contraindicated.
Pseudotruncus
        Defect which includes hypoplasia or absence of the main pulmonary artery. Pulmonary
            circulation is dependent upon a patent ductus arteriosus and VSD
    Clinical feature
        Resemble those of tricuspid atresia, dyspnea, fatigability, frequent respiratory infections,
            cyanosis, hypoxia, and cardiac failure are all common findings.
        Surgical correction involves closing the VSD and patent ductus arteriosus, Rastelli procedure.
Pulmonary Atresia
        Valvular pulmonary atresia is the failure of the development of the pulmonary valve and normal development of the right ventricular chamber.
        Arterial pulmonary atresia is failure of embryologic development of the main pulmonary artery.
        Circulation depends on the patent foramen ovale or the atrial septal defect and a patent ductus arteriosus.
    Clinical Features
        Severe cyanosis, clubbing, dyspnea, and fatigue are common.
        Complications include subacute bacterial endocarditis, brain abscess, embolism, and cerebral vascular accidents.
        Surgical correction depends on the RV development
            If right ventricle is normal a simple pulmonary valvulotomy may be performed.
            Right ventricular chamber hypoplastic with a normal pulmonary artery ( Cooley, Blalock-Taussig, Potts, Glenn Shunts,
                or the Rashkind procedure
            Main Pulmonary artery hypoplastic Fontan procedure
            Right ventricle normal pulmonary artery hypoplastic the Rastelli is effective
Pulmonary Stenosis
        Compromises 10-15% of congenital defects.
        Four types can occur
            1) Valvular Stenosis
            2) Infundibular stenosis (or combination of the two)
            3) Stenosis of the pulmonary artery (Supravalvular stenosis or coarctation of the PA)
            4) Peripheral pulmonary stenosis
        Causes obstruction of blood from the RV increasing the work load of the right ventricle.
        Pulmonary Stenosis may be described by RV pressure as the following:
            1) mild 45mmHg or less
            2) moderate 46-89 mmHg
            3) severe 90 mmHg or more
    Clinical Features
        Exertional dyspnea, and frank cardiac failure.
        systolic pressure gradient of 60mmHg or more indication of operation.
        If pure valvular fused commissures are incised by direct vision
        If infundibular hypertrophy in  the pulmonary outflow tract is resected.
Tetralogy of Fallot
        Consists of four distinct features:
            1) Pulmonary stenosis
            2) VSD
            3) Overriding aorta
            4) Right ventricular hypertrophy
        If ASD present Pentalogy of Fallot
    Clinical Features
        Cyanosis and clubbing common, Clotting abnormalities; hypoxic episodes, cerebral thrombosis, brain abscess
        and pulmonary hemorrhage are other occurrences
    Surgical palliation has been recommended for small infants
    1) Blalock-Taussig or 2) Potts
Total Anomalous Pulmonary Venous Return
        When four pulmonary veins return blood to the right side of the heart. Intracardiac defect
            must be present for left side circulation. Usually a ASD. Can also be partial left called
            Partial anomalous pulmonary return.
        Can fall into three categories.
            1) Supracardiac- most common type 50% pulmonary vein empties into left SVC,
                    then innominate vein and finally into the SVC.
            2) Cardiac- 30% return frequently empties into the coronary sinus, occasionally R. atrium
            3) Infracardiac- 10% return into a common venous trunk that descends and enters the IVC
                    or portal vein below the diaphragm.
    Clinical Feature
        Cyanosis characteristic of all types. Cardiac failure and pulmonary hypertension are consequential.
        Surgical treatment aimed at redirecting the venous return to the left side.
Transposition of the Great Vessels
         Complete transposition the aorta arises from the right ventricle and is located anterior
            to the pulmonary artery, pulmonary artery arises from the left ventricle and is posterior to
            the aorta. When this is present, normal circulation is interrupted and blood circulates around
            the systemic circulation without passing through the pulmonary circulation. A patent ductus
            arteriosus, patent foramen ovale are present in 50% of the cases, most common VSD.
    Clinical Features
        cyanosis, frequent respiratory infections, spells of hypoxia, or anoxia, myocardial infarction
        pulmonary hypertension, and congestive failure.
        Surgical correction Blalock-Hanlon
        Total correction of this defect involves rearranging the atrial septum so that the atrial
            chamber receiving blood from the superior and inferior vena cava will empty into the
            ventricle from which the pulmonary artery leaves, same for the systemic system.
            This rearranging procedure is the Mustard or Senning
 
Tricuspid Atresia
        Absence of tricuspid valve, prevents normal heart circulation. Blood must flow through a
            ASD or patent foramen ovale
        VSD or patent ductus arteriosus must be present for blood to get to pulmonary vessels.
      Clinical Feature
            high mortality rate, 50% die within six months.
            Severe cyanosis, clubbing, dyspnea, and fatigue common, as is right heart failure.
            Complications include subacute bacterial endocarditis, brain abscess, embolism,
                and cerebrovascular accidents.
            Surgical correction usually limited to increasing pulmonary blood flow
                1) Cooley shunt
                2) Blalock- Taussig
                3) Potts
                4) Glenn procedure
                5) Rashkind
Tricuspid Insufficiency
        Extremely rare finding; congenital or rheumatic disease, trauma or endocarditis occasionally
            cause tricuspid insufficiency.
        Clinical Feature
            Edema and ascites are usually present, also hepatomegaly, and splenomegaly.
            Primary cardiac defect must be corrected. Repair is usually limited to valvuloplasty.
Tricuspid Stenosis
        Rare instances is congenital. almost always due to rheumatic fever.
        Tricuspid commissures fuse and fibrose.
    Clinical Features
        right heart failure symptoms; edema, systemic venous hypertension, and ascites.
        Usually corrected by valvuloplasty unless a valve leaflet has been destroyed, in this case
            valve replacement is necessary
Truncus Arteriosus
        VSD with a single vessel, single ventricular valve. Pulmonary arteries may arise separately
        or from a common stem.
    Clinical Features
        PVR compared to SVR largely determines the clinical picture. If PVR low in comparison
            then pulmonary flow is normal or increased. cardiac failure.
        Dyspnea, fatigability, frequent respiratory infections, cyanosis, hypoxia, clubbing are all
            frequent findings.
        Surgical correction involves the closing of VSD, removing the pulmonary arteries from the
            wall of the truncus, and inserting a woven Dacron tube graft which incorporates  a
            prosthetic valve between RV and left pulmonary artery. Rastelli
Ventricular Septal Defect
        Four types: top to bottom of septal wall
            1) located between the crista supraventricularis and the pulmonary valve
            2) just caudal to the crista supraventricularis
            3) Beneath the septal leaflet of the tricuspid valve in an area where the A-V conduction bundle is susceptible to injury.
            4) located in the muscular septum near the apex of the right ventricle
    Clinical Features
        Size and pulmonary resistance determine the volume of blood shunted, increased pulmonary blood flow increased PVR
        When PVR becomes more pronounced (PVR higher than SVR) right to left shunt occurs once this happens surgical
            correction uniformly unsuccessful. Correction may be carried out by direct closure


Repair procedures:

Blalock-Hanlon- does not involve CPB involves excising a portion of the atrial septum
  Blalock-Taussig- right subclavian to pulmonary artery
  Cooley - aorta to right pulmonary artery
  Fontan- right atrium to the pulmonary artery
  Glenn- superior vena cava and right pulmonary artery.
  Jatene- descending aorta and main pulmonary artery are transected into normal fashion.
Le Compte- vessels transected but the ascending aorta is behind the pulmonary bifurcation.
Mustard- switching of the atrium in transposition of the great vessels by inflow inversion
Norwood- right atrium to pulmonary (modified Fontan) intra atrial baffle
Potts- aortic to left pulmonary artery
  Rashkind- pulling a balloon catheter through left atrium into right atrium Cath lab procedure (Atrial Septostomy)
  Rastelli- tube graft right ventricle and pulmonary artery
  Senning- switching of the atrium in transposition of the great vessels by inflow inversion.